CODEINE
The Addictive Morphine-Like Substance
What is Codeine?
Codeine is an opioid medication that turns into morphine when in the body. While it’s not nearly as powerful as pure morphine, in large quantities it can have similar effects. Codeine is typically found in cough syrups and in combination pain medications (e.g. T3s which are Tylenol and codeine combined). It acts as a depressant of the central nervous system, resulting in feelings of relaxation and drowsiness.
Drug Class
Codeine belongs to a class of medications called opiates as well as a class of medications called antitussives. As an opiate, it’s used to treat pain by changing the way that the brain and the nervous system respond to pain. As an antitussive, it suppresses coughing by decreasing the activity in the part of the brain that is responsible for coughing.
Drug Schedule
The Drug Enforcement Association (DEA) has a drug schedule that ranges from Schedule I to Schedule V. Drugs are categorized according to their medical use and potential for abuse on this schedule. Schedule I drugs have the highest potential for abuse and the lowest level of medical usefulness and Schedule IV drugs have the lowest potential for abuse and the highest level of medical usefulness.
In general, codeine is listed as a Schedule II controlled substance (substances with more than 90 mg).1 A Schedule II substance is one that has both a medically legitimate purpose but also carries a high potential for abuse. It also means that there are quotas on how much codeine can be produced, restrictions on the number of prescriptions, and punishments for illegal use.
Combination drugs that contain less than 90mg of codeine in them are classified as Schedule III controlled substances.1 Some medications such as Robitussin, which is cough syrup, contain very small amounts and are classified as Schedule V substances.
What is Codeine Used For?
Codeine is used for the relief of mild to moderate pain. When used in combination with other medications, it may be used to reduce coughing. Cough medication that includes the drug comes in a syrup form that is taken orally.
How is it Used?
Codeine, whether alone or in combination with other medications comes in the form of a tablet, capsule, and a liquid solution taken by mouth.2 It should always be taken as instructed by your doctor, however, some people misuse it.
When tablets are crushed and snorted, or when the liquid medication is mixed together with soda and drank, there is a much greater risk of addiction. Other ways this drug is misused includes taking it more frequently than prescribed, in higher doses than prescribed, and for longer than prescribed. It is also frequently misused in combination with alcohol and marijuana, which can increase the risk of an overdose.
Effects of Codeine
What are the Short-Term Effects?
Using codeine can result in any of the following short-term side-effects:
Agitation
Changes in heartbeat
Changes in vision
Confusion
Decreased sexual desire
Diarrhea
Difficulty breathing or swallowing
Difficulty urinating
Dizziness
Fever
Hallucinations
Headache
Hives
Irregular menstruation
Itching
Loss of coordination
Muscle twitching
Nausea
Noisy breathing
Rash
Seizures
Muscle stiffness
Shallow breathing
Shivering
Sweating
Vomiting
Weakness
What are the Long-Term Effects?
Prolonged use of codeine can lead to side effects that are more long-term. These include:
Addiction
Bowel damage
Brain damage
Depression
Gastrointestinal issues
Irregular heart rate
Liver malfunction (particularly with Tylenol combination medications)
Lung infections
Sleep disorders
Can You Overdose on Codeine?
Yes, you can overdose. Just like other opioids, you can overdose if you take too much at once.
Symptoms of overdose include:
Cold and clammy skin
Dizziness
Extreme fatigue
Intestinal spasms
Light-headedness
Loss of consciousness
Muscle twitching
Slow breathing
Weakness
Naloxone
In the event of an overdose, it is extremely important to seek emergency medical assistance immediately. Overdosing can be fatal so it is important to administer naloxone if available. Naloxone is a mediation that is used to reverse the life-threatening effects of an overdose. This medication can essentially “buy time” until you get to the hospital.
If one dose of naloxone is administered and symptoms of an overdose return after a few minutes, another dose of naloxone should be administered. Naloxone works by blocking off the effects of opioids in the brain, essentially reversing the effects. Reach out to your local healthcare provider for information on where to obtain naloxone kits.
Emergency Medical Help
Emergency medical help is still required in the event of an overdose, even after administering naloxone.
How Can You Safely Stop Using Codeine?
The safest way to stop opiate use is through medical detox. A medical detox program helps you to safely stop using an opiate by helping manage withdrawal symptoms and reduce the risk of relapse.
Suboxone is the most commonly used medication prescribed in the treatment of opioid addiction. Suboxone contains buprenorphine and naloxone which help to reduce cravings and help with withdrawal symptoms by replacing the codeine with Suboxone.
What are the Withdrawal Symptoms?
If you use codeine for a prolonged period, suddenly stopping it can lead to unpleasant withdrawal symptoms. Withdrawal symptoms occur when the body has developed a tolerance to and a dependence on the drug. The body learns to function with the presence of codeine, so its sudden absence causes negative effects.
Some withdrawal symptoms are:
Abdominal cramps
Dehydration
Enlarged pupils
Loss of appetite
Muscle pains
Nausea
Runny nose
Sweating
Teary eyes
Weight loss
Restlessness/irritability
Chills
Diarrhea
Backache
Is Codeine Addictive?
Yes, just like all other opioids, codeine can be highly addictive when taken in high doses and for a prolonged time. Codeine is a morphine-like substance that affects the brain’s reward center, resulting in feelings of euphoria, pleasure, wellbeing, and relaxation. It can also help to suppress negative feelings such as anxiety, stress, or depression. You are at particular risk of developing an addiction if you are abusing codeine.
What are the Rates of Codine Abuse in the United States?
Although there are fewer statistics on codeine use specifically, statistics on opioid use, in general, give us an idea of how big the problem of opioid abuse really is. The Substance Abuse and Mental Health Services Administration’s (SAMHSA) 2018 National Survey of Drug Use and Health states that in 2018, approximately 10.3 million people over the age of 12 reported misusing opioids.3 9.9 million of these people abused prescription pain killers such as codeine specifically, with the remainder of people abusing heroin.3
SAMSHA also reported that in the previous year, 0.9% of the population had abused codeine.3 It was the third most abused pain killer, coming after hydrocodone and oxycodone.3
Signs of Codeine Use
If you or someone you know is experiencing some or all of the symptoms below, it may be time to talk to someone about the effects of codeine and how it is impacting yours or your loved ones’ life.
Some of the symptoms of substance use disorder include:
Anxiety
Depression
Mood swings
Drowsiness
Sleeping more than usual
Decreased appetite/weight loss
Clammy hands/feet
Stomach pain/constipation
Itching
Confused mental state
Blue-ish lips/fingernails
Seizures/hallucinations
Other Signs of Substance Use Disorder
Using a great deal of effort to maintain a constant supply of the drug, like obtaining it without a prescription, illegally purchasing on the street, or stealing prescriptions
Experiencing strong urges and cravings
Using codeine in other ways than prescribed. For example, using a higher dosage than prescribed, taking it more frequently than prescribed, taking it for longer than prescribed, crushing and snorting it, or mixing the syrup with soda
Using the drug even after experiencing negative consequences like relationship problems, lack of responsibilities, not fulfilling home, work and school obligations, negative side effects, lack of interest in previously enjoyed hobbies
Experiencing withdrawal symptoms when not using codeine
Experiencing pain differently as a result of the excessive use of opioid pain medication
Treating Addiction
Treatment options for substance use disorder typically involve some form of counseling or therapy and medication-assisted therapy.
Medication-Assisted Therapy
Suboxone is the medication that is most commonly used for addiction treatment. Suboxone is made up of buprenorphine and naloxone which helps to reduce cravings and help with withdrawal symptoms. Suboxone works to replace the codeine in the body until it is no longer needed.
Counseling
In addition to medication-assisted therapy, an essential part of substance use disorder treatment is counseling, therapy, or peer support groups Counseling can take place at an inpatient facility or an outpatient facility. To be successful in treatment, it is important to tackle the underlying reasons that may have led to using or misusing substances.
Counseling and therapy can help to identify patterns surrounding substance abuse, problematic behaviors, healthy coping mechanisms, and overall improvement to your quality of life.
Treatment programs that include counseling can help you:
Learn relapse prevention skills, healthy boundaries, and communication skills
Engage in alternative recreational activities
Adopt skills that help to rebuild and maintain relationships
Receive education surrounding substance abuse disorders
Develop coping skills
Address any co-occurring disorders or mental illnesses
Support Groups
Peer support groups such as Narcotics Anonymous are also helpful for individuals who are looking to connect with people who are going through the same experience. Peer support groups can build a community of people who help to hold each other accountable as well as celebrate successes and milestones during treatment.
Substance use disorders can make you feel isolated from your friends and family, so having a strong support network is crucial. A support group can be made up of family, friends, colleagues, mentors, social workers, physicians, and more.
Find Help for Your Substance Use Disorder
The treatment of substance use disorders must address the whole person, including physical and mental health. Substance use disorders are typically affected by and affect various other aspects of your life. For example, a pre-existing mental health disorder might lead you to use substances to address untreated symptoms. A substance use disorder can also lead to mental health issues such as anxiety and depression. Because of the strong link that substance use disorders have to other aspects of your life, it is important the substance abuse treatment address all aspects of wellbeing.
Names for Codeine
What are the Brand Names?
Codeine is an opioid that is used in combination with many different medications, resulting in a lot of different brand names, depending on what combinations of medications are in the drug.2
When combined with the following drugs, the brand names of codeine combinations are:
Acetaminophen
Tylenol 3
Chlorpheniramine
Tuzistra
Cotab A
Notuss AC
Z Tuss AC
Zodryl AC
Phenylephrine
Airacof
Aka-Hist AC
Notuss PE
Guaifenesin
Allfen CD
Antituss AC
Bitex
Bronte
Bron-Tuss
Cheracol
Cheratussin
Codafen
Dex-Tuss
Diabetic Tussin
Duraganidin NR
ExeClear-C
Gani-Tuss NR
Glydeine
Guaifen AC
Guiatuss AC
Guiatussin
Halotussin AC
Iophen
Mar-cof CG
M-Clear WC
Mytussin AC
Robafen AC
Robichem AC
Robitussin AC
Romilar AC
Tussi Organidin
Tussiden C
Tusso-C
Bromodiphenhydramine
Ambenyl
Ambophen
Bromanyl
Bromotuss
Brovex CB
Brovex PBC
EndaCof AC
Nalex AC
Anhydrous Calcium Iodide
Calcidrine
Phenylephrine + Pyrilamine
Codimal PH
Dicomal PH
Chlorpheniramine + Phenylrephrine + Potassium Iodide
Demi-Cof
Pediacof
Pedituss
Diphenhydramine + Phenylephrine
Endal CD
Guaifenesin + Phenylephrine
Giltuss Ped-C
Maxiphen CD
Brompheniramine + Phenylephrine
M-End PE
Poly-Tussin AC
Phenylephrine + Promethazine
Pentazine VC
Phenergan VC
Promethazine
Pentazine
Phenergan
Guaifenesin + Promethazine
Prometh with Codeine
Ammonium Chloride + Chlorpheniramine + Phenylephrine
Rolatuss
Brompheniramine + Guaifenesin
Tusnel C
Caffeine + Pheniramine + Phenylephrine + Salicylic Acid
Tussirex
Dexchlorpheniramine + Phenylephrine
Vanacof
Phenylephrine + Pyrilamine
Zotex C
Street Names
- Lean
- Texas tea
- Purp
- Purple drank
- Sizzurp
- Pancakes and Syrup
- Captain cody
- Cody
- Little C
- School boy
- T1
- T2
- T3
- T4
- Doors
- Fours